What are the Medical Factors that may cause manic or depressive symptoms?
As shown in the below table, most of the medical conditions that can cause symptoms of mania or depression involve the neurologic or endocrine systems or infections/inflammatory conditions. Usually a careful patient history, as well as laboratory tests, can help the clinician rule out these medical causes.
Medical Conditions that May Cause Manic or Depressive Symptoms
| Manic Symptoms | Depressive Symptoms | |
| Neurologic | epilepsy, Huntington’s disease, CNS infections, multiple sclerosis, tumors, trauma | stroke, dementia (e.g., Alzheimer’s disease), Parkinson’s disease, hydrocephalus |
| Endocrine | blood glucose abnormalities | Addison’s disease, parathyroid disorders, postpartum depression, blood glucose abnormalities |
| Infections/ Inflammatory |
— | systemic lupus erythematosus, systemic infections |
| Other | hyperthyroidism, uremia, hemodialysis, postpartum mania, AIDS | cancer, AIDS, cardiopulmonary disease |
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